PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation

PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation

Summary: Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM inflammatory signaling and prevent lethal edema, the hallmark of acute lung injury (ALI), remain unknown. Here, we demon...

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Bibliographic Details
Main Authors: Sheikh Rayees, Jagdish Chandra Joshi, Mohammad Tauseef, Mumtaz Anwar, Sukriti Baweja, Ian Rochford, Bhagwati Joshi, Morley D. Hollenberg, Sekhar P. Reddy, Dolly Mehta
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719303833

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http://www.sciencedirect.com/science/article/pii/S2211124719303833

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