Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis

Several reports have shown that thymoquinone (TQ) effectively attenuates angiogenesis in cancer cells, resulting in suppression of tumor growth. However, it is not yet clear whether TQ reduces hypoxia-inducible factor-1α (HIF-1α) expression in hypoxic cancer cells. Here, we found that TQ was a novel...

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Bibliographic Details
Main Authors: Yoon-Mi Lee, Geon-Hee Kim, Eun-Ji Park, Taek-In Oh, Sujin Lee, Sang-Yeon Kan, Hyeji Kang, Byeong Mo Kim, Ji Hyung Kim, Ji-Hong Lim
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/20/5/1092