Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis

Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis

Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon cancer (HCT-116), and liver cancer (HepG-2) activities. The structural identity of the synthesized compounds was established...

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Bibliographic Details
Main Authors: Fawzia F. Alblewi, Rawda M. Okasha, Areej A. Eskandrani, Tarek H. Afifi, Hany M. Mohamed, Ahmed H. Halawa, Ahmed M. Fouda, Al-Anood M. Al-Dies, Ahmed Mora, Ahmed M. El-Agrody
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
fused chromenes and pyrimidines
cell cycle analysis
cell apoptosis
caspase 3/7 activity
DNA fragmentation
cell invasion
and migration
SAR
Online Access:http://www.mdpi.com/1420-3049/24/6/1060

Internet

http://www.mdpi.com/1420-3049/24/6/1060

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