Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury

Perturbation of mitochondrial function and subsequent induction of cell death pathways are key hallmarks in neonatal hypoxic-ischemic (HI) injury, both in animal models and in term infants. Mitoprotective therapies therefore offer a new avenue for intervention for the babies who suffer life-long dis...

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Bibliographic Details
Main Authors: Ana A. Baburamani, Chloe Hurling, Helen Stolp, Kristina Sobotka, Pierre Gressens, Henrik Hagberg, Claire Thornton
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
OPA1
Oma1
Yme1L
oxygen-glucose deprivation (OGD)
hypoxia-ischaemia
neonatal brain injury
Online Access:http://www.mdpi.com/1422-0067/16/9/22509

Internet

http://www.mdpi.com/1422-0067/16/9/22509

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