Validation of a Bioinformatics Workflow for Routine Analysis of Whole-Genome Sequencing Data and Related Challenges for Pathogen Typing in a European National Reference Center: Neisseria meningitidis as a Proof-of-Concept

Validation of a Bioinformatics Workflow for Routine Analysis of Whole-Genome Sequencing Data and Related Challenges for Pathogen Typing in a European National Reference Center: Neisseria meningitidis as a Proof-of-Concept

Despite being a well-established research method, the use of whole-genome sequencing (WGS) for routine molecular typing and pathogen characterization remains a substantial challenge due to the required bioinformatics resources and/or expertise. Moreover, many national reference laboratories and cent...

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Bibliographic Details
Main Authors: Bert Bogaerts, Raf Winand, Qiang Fu, Julien Van Braekel, Pieter-Jan Ceyssens, Wesley Mattheus, Sophie Bertrand, Sigrid C. J. De Keersmaecker, Nancy H. C. Roosens, Kevin Vanneste
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
Neisseria meningitidis
whole-genome sequencing
validation
public health
national reference center
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00362/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00362/full

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