Facile Synthesis and In Vitro Activity of <i>N</i>-Substituted 1,2-Benzisothiazol-3(2<i>H</i>)-ones against Dengue Virus NS2BNS3 Protease

Facile Synthesis and In Vitro Activity of <i>N</i>-Substituted 1,2-Benzisothiazol-3(2<i>H</i>)-ones against Dengue Virus NS2BNS3 Protease

Several new <i>N</i>-substituted 1,2-benzisothiazol-3(2<i>H</i>)-ones (BITs) were synthesised through a facile synthetic route for testing their anti-dengue protease inhibition. Contrary to the conventional multistep synthesis, we achieved structurally diverse BITs with excel...

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Bibliographic Details
Main Authors: Farwa Batool, Muhammad Saeed, Hafiza Nosheen Saleem, Luisa Kirschner, Jochen Bodem
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pathogens
Subjects:
dengue virus
direct-acting antivirals
1,2-benzisothiazolinone
drug discovery
infectivity assays
Online Access:https://www.mdpi.com/2076-0817/10/4/464

Internet

https://www.mdpi.com/2076-0817/10/4/464

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