A Cytosolic Sensor, PmDDX41, Binds Double Stranded-DNA and Triggers the Activation of an Innate Antiviral Response in the Shrimp Penaeus monodon via the STING-Dependent Signaling Pathway

A Cytosolic Sensor, PmDDX41, Binds Double Stranded-DNA and Triggers the Activation of an Innate Antiviral Response in the Shrimp Penaeus monodon via the STING-Dependent Signaling Pathway

Helicase DDX41 is a cytosolic sensor capable of detecting double-stranded DNA in mammals. However, the function of DDX41 remains poorly understood in invertebrates. In a previous study, we identified the first DDX41 sensor in the black tiger shrimp Penaeus monodon (PmDDX41) and showed that it played...

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Bibliographic Details
Main Authors: Suthinee Soponpong, Piti Amparyup, Taro Kawai, Anchalee Tassanakajon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
antiviral immune response
DDX41
immune signaling pathway
Penaeus monodon
STING
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02069/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02069/full

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