Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions. We now demonstrate that the endogenous alarmins MRP8 and MRP14 induce phagocy...

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Main Authors: Judith Austermann, Judith Friesenhagen, Selina Kathleen Fassl, Theresa Ortkras, Johanna Burgmann, Katarzyna Barczyk-Kahlert, Eugen Faist, Siegfried Zedler, Sabine Pirr, Christian Rohde, Carsten Müller-Tidow, Maren von Köckritz-Blickwede, Constantin S. von Kaisenberg, Stefanie B. Flohé, Thomas Ulas, Joachim L. Schultze, Johannes Roth, Thomas Vogl, Dorothee Viemann
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009747