Novel Missense Mutation in the NOD2 Gene in a Patient with Early Onset Ulcerative Colitis: Causal or Chance Association?

Novel Missense Mutation in the NOD2 Gene in a Patient with Early Onset Ulcerative Colitis: Causal or Chance Association?

Deregulated immune response to gut microflora in genetically predisposed individuals is typical for inflammatory bowel diseases. It is reasonable to assume that genetic association with the disease will be more pronounced in subjects with early onset than adult onset. The nucleotide-binding oligomer...

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Bibliographic Details
Main Authors: Martina Girardelli, Josef Vuch, Alberto Tommasini, Sergio Crovella, Anna Monica Bianco
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
complex disease
digenic heterozygosis
early onset-inflammatory bowel disease
IL10R
NOD2
Online Access:http://www.mdpi.com/1422-0067/15/3/3834

Internet

http://www.mdpi.com/1422-0067/15/3/3834

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