The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats

The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats

OBJECTIVE: The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. METHODS: First, amitriptyline was administered intraperitoneally (i.p.) at doses of 20, 40 and 80 mg kg-1, 30 min before subpl...

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Bibliographic Details
Main Authors: Valiollah Hajhashemi, Hossein Sadeghi, Mohsen Minaiyan, Ahmad Movahedian, Ardeshir Talebi
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2010-01-01
Series:Clinics
Subjects:
Amitriptyline
Carrageenan
Edema
Intracerebroventricular
Intrathecal
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100022

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100022

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