Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Curcumin and o-Vanillin cleared senescent intervertebral disc (IVD) cells and reduced the senescence-associated secretory phenotype (SASP) associated with inflammation and back pain. Cells from degenerate and non-mildly-degenerate human IVD were obtained from organ donors and from patients undergoin...

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Bibliographic Details
Main Authors: Hosni Cherif, Daniel G. Bisson, Peter Jarzem, Michael Weber, Jean A. Ouellet, Lisbet Haglund
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Journal of Clinical Medicine
Subjects:
intervertebral disc
senescence
degeneration
inflammation
senolytics
back pain
Online Access:https://www.mdpi.com/2077-0383/8/4/433

Internet

https://www.mdpi.com/2077-0383/8/4/433

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