Compensatory responses induced by oxidative stress in Alzheimer disease

Compensatory responses induced by oxidative stress in Alzheimer disease

Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as...

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Bibliographic Details
Main Authors: PAULA I MOREIRA, XIONGWEI ZHU, QUAN LIU, KAZUHIRO HONDA, SANDRA L SIEDLAK, PEGGY L HARRIS, MARK A. SMITH, GEORGE PERRY
Format: Article
Language:English
Published: BMC 2006-01-01
Series:Biological Research
Subjects:
Alzheimer disease
antioxidant therapy
mitochondria
oxidative stress
redox metals
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100002
Description
Summary:Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.
ISSN:0716-9760
0717-6287

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