Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.

Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.

Isoniazid represents a first-line anti-tuberculosis medication in prevention and treatment. This prodrug is activated by a mycobacterial catalase-peroxidase enzyme called KatG in Mycobacterium tuberculosis), thereby inhibiting the synthesis of mycolic acid, required for the mycobacterial cell wall....

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Bibliographic Details
Main Authors: Paolo Ascenzi, Andrea Coletta, Yu Cao, Viviana Trezza, Loris Leboffe, Gabriella Fanali, Mauro Fasano, Alessandra Pesce, Chiara Ciaccio, Stefano Marini, Massimo Coletta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936350/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936350/?tool=EBI

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