Extensive Multiple Sclerosis Reactivation after Switching from Fingolimod to Rituximab

During treatment with fingolimod, B cells are redistributed from blood to secondary lymphoid organs, where they are protected from the effect of anti-CD20 and other cell-depleting therapies. We describe a multiple sclerosis patient who had almost complete depletion of B cells in blood during and sho...

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Bibliographic Details
Main Authors: Trygve Holmøy, Øivind Torkildsen, Svetozar Zarnovicky
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/2018/5190794