Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis

Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis

Humanized mouse models are useful tools to explore the functional and regulatory differences between human and murine orthologous genes. We have combined a bioinformatics approach and an in vivo approach to assess the functional and regulatory differences between the human and mouse ABCA1 genes. Com...

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Bibliographic Details
Main Authors: Jonathan M. Coutinho, Roshni R. Singaraja, Martin Kang, David J. Arenillas, Lisa N. Bertram, Nagat Bissada, Bart Staels, Jean-Charles Fruchart, Catherine Fievet, Ann M. Joseph-George, Wyeth W. Wasserman, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette type A1
humanized mouse
bacterial artificial chromosome
phylogenetic footprinting
liver X receptor
transcription factor binding site
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330170

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http://www.sciencedirect.com/science/article/pii/S0022227520330170

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