Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia

In two recent double-blind clinical trials of fetal ventral mesencephalic cell transplants into the striatum in patients with Parkinson's disease (PD), a significant proportion of the grafted patients developed dyskinetic side effects, which were not seen in the sham operated patients. Comparis...

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Bibliographic Details
Main Authors: Thomas Carlsson, Christian Winkler, Martin Lundblad, M. Angela Cenci, Anders Björklund, Deniz Kirik
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002536