Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy
Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix componen...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/20/6/1263 |
id |
doaj-d92dd51c53ae405c985402da1a72856e |
---|---|
record_format |
Article |
spelling |
doaj-d92dd51c53ae405c985402da1a72856e2020-11-24T21:15:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206126310.3390/ijms20061263ijms20061263Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor EfficacyMarta Truffi0Serena Mazzucchelli1Arianna Bonizzi2Luca Sorrentino3Raffaele Allevi4Renzo Vanna5Carlo Morasso6Fabio Corsi7Department of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyDepartment of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyNanomedicine and Molecular Imaging Lab, Istituti Clinici Scientifici Maugeri IRCCS, via Maugeri 4, 27100 Pavia, ItalyNanomedicine and Molecular Imaging Lab, Istituti Clinici Scientifici Maugeri IRCCS, via Maugeri 4, 27100 Pavia, ItalyDepartment of Biomedical and Clinical Sciences “L. Sacco”, Università degli studi di Milano, via G. B. Grassi 74, 20157 Milano, ItalyCancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix components, neovessels, and deregulated immune cells, is associated with poor prognosis in multiple carcinomas, including breast cancer. Therefore, beyond cancer cells killing, researchers are currently focusing on TME as strategy to fight breast cancer. In recent years, nanomedicine has provided a number of smart delivery systems based on active targeting of breast CAF and immune-mediated overcome of chemoresistance. Many efforts have been made both to eradicate breast CAF and to reshape their identity and function. Nano-strategies for CAF targeting profoundly contribute to enhance chemosensitivity of breast tumors, enabling access of cytotoxic T-cells and reducing immunosuppressive signals. TME rearrangement also includes reorganization of the extracellular matrix to enhance permeability to chemotherapeutics, and nano-systems for smart coupling of chemo- and immune-therapy, by increasing immunogenicity and stimulating antitumor immunity. The present paper reviews the current state-of-the-art on nano-strategies to target breast CAF and TME. Finally, we consider and discuss future translational perspectives of proposed nano-strategies for clinical application in breast cancer.http://www.mdpi.com/1422-0067/20/6/1263cancer-associated fibroblaststumor microenvironmentnanoparticlesbreast cancerantitumor efficacy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Truffi Serena Mazzucchelli Arianna Bonizzi Luca Sorrentino Raffaele Allevi Renzo Vanna Carlo Morasso Fabio Corsi |
spellingShingle |
Marta Truffi Serena Mazzucchelli Arianna Bonizzi Luca Sorrentino Raffaele Allevi Renzo Vanna Carlo Morasso Fabio Corsi Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy International Journal of Molecular Sciences cancer-associated fibroblasts tumor microenvironment nanoparticles breast cancer antitumor efficacy |
author_facet |
Marta Truffi Serena Mazzucchelli Arianna Bonizzi Luca Sorrentino Raffaele Allevi Renzo Vanna Carlo Morasso Fabio Corsi |
author_sort |
Marta Truffi |
title |
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy |
title_short |
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy |
title_full |
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy |
title_fullStr |
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy |
title_full_unstemmed |
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy |
title_sort |
nano-strategies to target breast cancer-associated fibroblasts: rearranging the tumor microenvironment to achieve antitumor efficacy |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix components, neovessels, and deregulated immune cells, is associated with poor prognosis in multiple carcinomas, including breast cancer. Therefore, beyond cancer cells killing, researchers are currently focusing on TME as strategy to fight breast cancer. In recent years, nanomedicine has provided a number of smart delivery systems based on active targeting of breast CAF and immune-mediated overcome of chemoresistance. Many efforts have been made both to eradicate breast CAF and to reshape their identity and function. Nano-strategies for CAF targeting profoundly contribute to enhance chemosensitivity of breast tumors, enabling access of cytotoxic T-cells and reducing immunosuppressive signals. TME rearrangement also includes reorganization of the extracellular matrix to enhance permeability to chemotherapeutics, and nano-systems for smart coupling of chemo- and immune-therapy, by increasing immunogenicity and stimulating antitumor immunity. The present paper reviews the current state-of-the-art on nano-strategies to target breast CAF and TME. Finally, we consider and discuss future translational perspectives of proposed nano-strategies for clinical application in breast cancer. |
topic |
cancer-associated fibroblasts tumor microenvironment nanoparticles breast cancer antitumor efficacy |
url |
http://www.mdpi.com/1422-0067/20/6/1263 |
work_keys_str_mv |
AT martatruffi nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT serenamazzucchelli nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT ariannabonizzi nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT lucasorrentino nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT raffaeleallevi nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT renzovanna nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT carlomorasso nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy AT fabiocorsi nanostrategiestotargetbreastcancerassociatedfibroblastsrearrangingthetumormicroenvironmenttoachieveantitumorefficacy |
_version_ |
1716744036179509248 |