Sequence-to-function deep learning frameworks for engineered riboregulators

The design of synthetic biology circuits remains challenging due to poorly understood design rules. Here the authors introduce STORM and NuSpeak, two deep-learning architectures to characterize and optimize toehold switches.

Bibliographic Details
Main Authors: Jacqueline A. Valeri, Katherine M. Collins, Pradeep Ramesh, Miguel A. Alcantar, Bianca A. Lepe, Timothy K. Lu, Diogo M. Camacho
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18676-2