High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

High prevalence of Pfdhfr–Pfdhps quadruple mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

Abstract Background Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthas...

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Bibliographic Details
Main Authors: Tingting Jiang, Jiangtao Chen, Hongxia Fu, Kai Wu, Yi Yao, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko Ondo Obono, Weixing Du, Huabing Tan, Min Lin, Jian Li
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Sulfadoxine–pyrimethamine
Anti-malarial drug resistance
Dihydropteroate synthase
Dihydrofolate reductase
Bioko Island
Online Access:http://link.springer.com/article/10.1186/s12936-019-2734-x

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http://link.springer.com/article/10.1186/s12936-019-2734-x

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