Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice.

microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators. Although miR155 is considered to be a pro-inflammatory microRNA, in vitro reports show anti-inflammatory effects in lipid-loaded cells. In this study we examined the role of miR155 in atherosc...

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Bibliographic Details
Main Authors: Marjo M P C Donners, Ine M J Wolfs, Lauran J Stöger, Emiel P C van der Vorst, Chantal C H Pöttgens, Stephane Heymans, Blanche Schroen, Marion J J Gijbels, Menno P J de Winther
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338496?pdf=render