Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system. Here, we report that the stinging nettle lectin (UDA), with predominant N-acetylglucosamine-...

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Bibliographic Details
Main Authors: Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Els J M Van Damme, Jan Balzarini, Dolores González-Pacanowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4351956?pdf=render

Internet

http://europepmc.org/articles/PMC4351956?pdf=render

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