The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.
The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that mas...
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2009-02-01
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doaj-d936a21983004c358a11167c186101982021-07-02T10:14:27ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852009-02-0172e4010.1371/journal.pbio.1000040The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.Wouter BossuytNatalie De GeestStein AertsIris LeenaertsPeter MarynenBassem A HassanThe acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of differentiation may be key regulators of tumor formation. Using loss- and gain-of-function analyses in Drosophila, we describe a critical anti-oncogenic function for the atonal transcription factor in the fly retina, where atonal instructs tissue differentiation. In the tumor context, atonal acts by regulating cell proliferation and death via the JNK stress response pathway. Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis.http://europepmc.org/articles/PMC2652389?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wouter Bossuyt Natalie De Geest Stein Aerts Iris Leenaerts Peter Marynen Bassem A Hassan |
spellingShingle |
Wouter Bossuyt Natalie De Geest Stein Aerts Iris Leenaerts Peter Marynen Bassem A Hassan The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biology |
author_facet |
Wouter Bossuyt Natalie De Geest Stein Aerts Iris Leenaerts Peter Marynen Bassem A Hassan |
author_sort |
Wouter Bossuyt |
title |
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
title_short |
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
title_full |
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
title_fullStr |
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
title_full_unstemmed |
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
title_sort |
atonal proneural transcription factor links differentiation and tumor formation in drosophila. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2009-02-01 |
description |
The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of differentiation may be key regulators of tumor formation. Using loss- and gain-of-function analyses in Drosophila, we describe a critical anti-oncogenic function for the atonal transcription factor in the fly retina, where atonal instructs tissue differentiation. In the tumor context, atonal acts by regulating cell proliferation and death via the JNK stress response pathway. Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis. |
url |
http://europepmc.org/articles/PMC2652389?pdf=render |
work_keys_str_mv |
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