An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells

An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells

Oligosaccharides aberrantly expressed on tumor cells influence processes such as cell adhesion and modulation of the cell’s microenvironment resulting in an increased malignancy. Schmidt’s imidate strategy offers an effective method to synthesize libraries of various oligosaccharide mimetics. With t...

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Bibliographic Details
Main Authors: Grazia Marano, Claas Gronewold, Martin Frank, Anette Merling, Christian Kliem, Sandra Sauer, Manfred Wiessler, Eva Frei, Reinhard Schwartz-Albiez
Format: Article
Language:English
Published: Beilstein-Institut 2012-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
angiogenesis
biomimetic synthesis
carbohydrates
in silico blind docking
melanoma cells
Online Access:https://doi.org/10.3762/bjoc.8.89

Internet

https://doi.org/10.3762/bjoc.8.89

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