Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls

Abstract Changes in immune function are associated with variance in cognitive functioning in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we examined whether schizophrenia risk-associated microglial genes (measured via polygenic score analysis) explained vari...

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Bibliographic Details
Main Authors: Emma Corley, Laurena Holleran, Laura Fahey, Aiden Corvin, Derek W. Morris, Gary Donohoe
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01616-z