Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonged inhibition of FAOX would presumably cause lipid...

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Bibliographic Details
Main Authors: Anne-Marie Lundsgaard, Andreas M. Fritzen, Trine S. Nicolaisen, Christian S. Carl, Kim A. Sjøberg, Steffen H. Raun, Anders B. Klein, Eva Sanchez-Quant, Jakob Langer, Cathrine Ørskov, Christoffer Clemmensen, Matthias H. Tschöp, Erik A. Richter, Bente Kiens, Maximilian Kleinert
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Lipid Research
Subjects:
carnitine palmitoyltransferase 1
mitochondrial long-chain fatty acid import
hepatic glucose production
brown adipose tissue
liver
hyperglycemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520300122

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http://www.sciencedirect.com/science/article/pii/S0022227520300122

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