Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Chemogenetics uses engineered proteins that are controlled by small molecule actuators, allowing in vivo functional studies of proteins with temporal and dose control, and include Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). One major class of DREADDs are mutated muscarinic...

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Bibliographic Details
Main Authors: Phillip L. van der Peet, Christian Gunawan, Alaa Abdul-Ridha, Sherie Ma, Daniel J. Scott, Andrew L. Gundlach, Ross A.D. Bathgate, Jonathan M. White, Spencer J. Williams
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:MethodsX
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016118300402

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http://www.sciencedirect.com/science/article/pii/S2215016118300402

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