Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited due to poorly developed follicular dendritic cells (FDC), causing generation of few antibody-secreting cells (ASCs) with limited survival and transient antibody responses....

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Bibliographic Details
Main Authors: Audur Anna Aradottir Pind, Magdalena Dubik, Sigrun Thorsdottir, Andreas Meinke, Ali M. Harandi, Jan Holmgren, Giuseppe Del Giudice, Ingileif Jonsdottir, Stefania P. Bjarnarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
vaccination
neonate
adjuvant
germinal center
antibody-secreting cell persistence
spleen
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02214/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02214/full

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