CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). CS-semi5 treatment had obvious effects on...

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Bibliographic Details
Main Authors: Xiang Li, Xiaonan Tang, Yufei Wang, Changwei Chai, Zhehui Zhao, Haijing Zhang, Ying Peng, Lianqiu Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
synovial inflammation
cartilage erosion
bone loss
chondroitin sulfate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.655101/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.655101/full

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