Phosphorylation at Carboxyl-Terminal S373 and S375 Residues and 14-3-3 Binding Are Not Required for Mouse p53 Function

Phosphorylation at Carboxyl-Terminal S373 and S375 Residues and 14-3-3 Binding Are Not Required for Mouse p53 Function

-γ-Irradiation- mediated ataxia telangiectasia mutated (ATM)-dependent dephosphorylation of serine 376 (S376) at the carboxyl terminus of human p53 results in the exposure of the 14-3-3 consensus-binding site, which includes serine 378 (S378).14-3-3 binding potentiates p53's DNA-binding abilit...

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Bibliographic Details
Main Authors: Ming Kei Lee, Kanaga Sabapathy
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
14-3-3 binding
mouse p53
S373
S375
phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800285

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http://www.sciencedirect.com/science/article/pii/S1476558607800285

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