Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Abstract Background Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs, are involved in anti-tumor immune surveillance and are functionally re...

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Bibliographic Details
Main Authors: Fleur S. Peters, Annemiek M. A. Peeters, Pooja R. Mandaviya, Joyce B. J. van Meurs, Leo J. Hofland, Jacqueline van de Wetering, Michiel G. H. Betjes, Carla C. Baan, Karin Boer
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
T lymphocytes
Epigenetics
Cutaneous squamous cell carcinoma
Non-melanoma skin cancer
Solid organ transplantation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0519-7

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http://link.springer.com/article/10.1186/s13148-018-0519-7

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