BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
Abstract Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts...
Main Authors: | Thomas C. Roberts, Usue Etxaniz, Alessandra Dall’Agnese, Shwu-Yuan Wu, Cheng-Ming Chiang, Paul E. Brennan, Matthew J. A. Wood, Pier Lorenzo Puri |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-07-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-06483-7 |
Similar Items
-
BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell.
by: Jude T Deeney, et al.
Published: (2016-01-01) -
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
by: Adam P. Cribbs, et al.
Published: (2021-02-01) -
Zebrafish <it>brd2a </it>and <it>brd2b </it>are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence
by: Bee Katharine J, et al.
Published: (2008-04-01) -
Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
by: Martin Hügle, et al.
Published: (2016-06-01) -
Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
by: Ranran Wang, et al.
Published: (2020-06-01)