IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

Abstract Background Immunosuppressive and anti-cytokine treatment may have a protective effect for patients with COVID-19. Understanding the immune cell states shared between COVID-19 and other inflammatory diseases with established therapies may help nominate immunomodulatory therapies. Methods To...

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Bibliographic Details
Main Authors: Fan Zhang, Joseph R. Mears, Lorien Shakib, Jessica I. Beynor, Sara Shanaj, Ilya Korsunsky, Aparna Nathan, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Laura T. Donlin, Soumya Raychaudhuri
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Medicine
Subjects:
Single-cell transcriptomics
Single-cell multi-disease tissue integration
COVID-19
Inflammatory diseases
Macrophage stimulation
Macrophage heterogeneity
Online Access:https://doi.org/10.1186/s13073-021-00881-3

Internet

https://doi.org/10.1186/s13073-021-00881-3

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