Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae

Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae

Members of the high temperature requirement A (HtrA) family of chaperone proteases have been shown to play a role in bacterial pathogenesis. In a recent report, we demonstrated that the gene ML0176, which codes for a predicted HtrA-like protease, a gene conserved in other species of mycobacteria, is...

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Bibliographic Details
Main Authors: Michelle Lopes Ribeiro-Guimarães, Eliana Blini Marengo, Antonio Jorge Tempone, Julio Jablonski Amaral, Clécio F Klitzke, Erika K Xavier da Silveira, Fernanda Calheta Vieira Portaro, Maria Cristina Vidal Pessolani
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Mycobacterium leprae
HtrA2
protease
enzymatic activity
FRET peptides
pathogenesis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800010

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