Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring

Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring

Background: Prenatal stress (PS) leads to a wide variety of behavioral and emotional aberration observed in later life, particularly in the impairment of spatial learning and memory in offspring. Icariin (ICA) is a naturally occurring furanocoumarin and exhibits many pharmacological properties, incl...

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Bibliographic Details
Main Authors: Xing xing Zheng, Yi wei Chen, Yi song Yue, Ying chun Li, Si zhe Xia, Yang Li, Huan huan Deng, Jiao He, Yan jun Cao
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Icariin
Learning and memory
CREB
Prenatal stress
HPA axis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219311977

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http://www.sciencedirect.com/science/article/pii/S0753332219311977

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