Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice

Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice

Chemerin, acting through its receptor ChemR23, is an adipokine associated with inflammatory response, glucose and lipid metabolism and vascular function. Although this adipokine has been associated with the development and progression of kidney disease, it is not clear whether the chemerin/ChemR23 s...

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Bibliographic Details
Main Authors: Karla Bianca Neves, Augusto Cesar Montezano, Rheure Alves-Lopes, Thiago Bruder-Nascimento, Rafael Menezes Costa, Roberto S Costa, Rhian M Touyz, Rita C Tostes
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
chemerin
ChemR23
kidney
type 2 diabetes
oxidative stress
Online Access:http://www.mdpi.com/1422-0067/19/8/2454

Internet

http://www.mdpi.com/1422-0067/19/8/2454

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