New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.

New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors.

BACKGROUND: Multi-drug resistant (MDR) bacteria have become a major concern in hospitals worldwide and urgently require the development of new antibacterial molecules. Peptide deformylase is an intracellular target now well-recognized for the design of new antibiotics. The bacterial susceptibility t...

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Bibliographic Details
Main Authors: Laurent Mamelli, Sylvain Petit, Jacqueline Chevalier, Carmela Giglione, Aurélie Lieutaud, Thierry Meinnel, Isabelle Artaud, Jean-Marie Pagès
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2713832?pdf=render

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http://europepmc.org/articles/PMC2713832?pdf=render

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