Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

Rapid Induction of Multifunctional Antibodies in Rabbits and Macaques by Clade C HIV-1 CAP257 Envelopes Circulating During Epitope-Specific Neutralization Breadth Development

We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy similar to a recent clinical trial that showed improved speed and magnitude of humoral responses. Clade C envelopes were isolated from CAP257, an...

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Bibliographic Details
Main Authors: Delphine C. Malherbe, Constantinos Kurt Wibmer, Molati Nonyane, Jason Reed, D. Noah Sather, David A. Spencer, Jason T. Schuman, Biwei Guo, Shilpi Pandey, Harlan Robins, Byung Park, Deborah H. Fuller, Jonah B. Sacha, Penny L. Moore, Ann J. Hessell, Nancy L. Haigwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
HIV vaccine
envelope immunogen
rabbit
NHP
neutralizing antibodies
co-immunization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00984/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00984/full

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