Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

BACKGROUND: The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections. METHODOLOGY: In this work, a small-molecule inhibitor of the WNV NS3pro has been identified b...

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Bibliographic Details
Main Authors: Dariusz Ekonomiuk, Xun-Cheng Su, Kiyoshi Ozawa, Christophe Bodenreider, Siew Pheng Lim, Zheng Yin, Thomas H Keller, David Beer, Viral Patel, Gottfried Otting, Amedeo Caflisch, Danzhi Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2613028?pdf=render

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http://europepmc.org/articles/PMC2613028?pdf=render

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