Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact. Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if IRF6 and TGFA interaction contributes to CL/P. Markers within and flanking IRF6 and TGFA genes...

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Bibliographic Details
Main Authors: Ariadne Letra, Walid Fakhouri, Renata F Fonseca, Renato Menezes, Inga Kempa, Joanne L Prasad, Toby G McHenry, Andrew C Lidral, Lina Moreno, Jeffrey C Murray, Sandra Daack-Hirsch, Mary L Marazita, Eduardo E Castilla, Baiba Lace, Ieda M Orioli, Jose M Granjeiro, Brian C Schutte, Alexandre R Vieira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3447924?pdf=render

Internet

http://europepmc.org/articles/PMC3447924?pdf=render

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