Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys

Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys

Behavioral studies have shown spatial working memory impairment with aging in several animal species, including humans. Persistent activity of layer 3 pyramidal dorsolateral prefrontal cortex (dlPFC) neurons during delay periods of working memory tasks is important for encoding memory of the stimulu...

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Bibliographic Details
Main Authors: Sara Ibañez, Jennifer I. Luebke, Wayne Chang, Danel Draguljić, Christina M. Weaver
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Computational Neuroscience
Subjects:
bump attractor
patch clamp
persistent activity
prefrontal cortex
synaptic plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fncom.2019.00089/full

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https://www.frontiersin.org/article/10.3389/fncom.2019.00089/full

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