Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have been synthesized in order to compare their biolog...

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Bibliographic Details
Main Authors: Raül Agut, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Alberto Marco
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
combretastatin a-4
3′-aminocombretastatin a-4
cytotoxicity
tubulin
microtubules
cell cycle
<i>vegf</i>
<i>htert</i>
c-<i>myc</i>
Online Access:https://www.mdpi.com/1420-3049/25/3/660

Internet

https://www.mdpi.com/1420-3049/25/3/660

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