In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis.

In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis.

Effectiveness of ART regimens strongly depends upon complex interactions between the selective pressure of drugs and the evolution of mutations that allow or restrict drug resistance.Four clinical isolates from NRTI-exposed, NNRTI-naive subjects were passaged in increasing concentrations of NVP in c...

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Bibliographic Details
Main Authors: Barbara A Rath, Kaveh Pouran Yousef, David K Katzenstein, Robert W Shafer, Christof Schütte, Max von Kleist, Thomas C Merigan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3629221?pdf=render

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http://europepmc.org/articles/PMC3629221?pdf=render

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