Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells

Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells

Intracerebral delivery of hCNTF has shown considerable neuroprotective potential in animal models of Huntington's disease (HD). The present study describes the relationship between a range of hCNTF doses and the resulting behavioral and neurochemical (striatal ChAT and GAD activity) protection...

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Main Author: Dwaine F. Emerich Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2004-10-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000004783983404
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spelling doaj-d98ce942b3854d85b562de9213ec67742020-11-25T03:33:14ZengSAGE PublishingCell Transplantation0963-68971555-38922004-10-011310.3727/000000004783983404Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing CellsDwaine F. Emerich Ph.D.0LCT BioPharma, Inc., 241 Anan Wade Road, Glocester, RI 02857Intracerebral delivery of hCNTF has shown considerable neuroprotective potential in animal models of Huntington's disease (HD). The present study describes the relationship between a range of hCNTF doses and the resulting behavioral and neurochemical (striatal ChAT and GAD activity) protection in a rodent model of HD. Encapsulated BHK delivering a range of hCNTF doses were implanted into the lateral ventricle ipsilateral to an intrastriatal quinolinic acid (QA) injection. Results demonstrated a dose-dependent effect of hCNTF with complete, partial, and no observable neuroprotection occurring with preimplant doses of hCNTF of 30.8, 8.6, and 0.8–2.1 ng hCNTF/24 h, respectively. These data continue to support the use of cellular delivery of hCNTF for HD and will facilitate the optimization of this approach in the clinical situation.https://doi.org/10.3727/000000004783983404
collection DOAJ
language English
format Article
sources DOAJ
author Dwaine F. Emerich Ph.D.
spellingShingle Dwaine F. Emerich Ph.D.
Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
Cell Transplantation
author_facet Dwaine F. Emerich Ph.D.
author_sort Dwaine F. Emerich Ph.D.
title Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
title_short Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
title_full Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
title_fullStr Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
title_full_unstemmed Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
title_sort dose-dependent neurochemical and functional protection afforded by encapsulated cntf-producing cells
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2004-10-01
description Intracerebral delivery of hCNTF has shown considerable neuroprotective potential in animal models of Huntington's disease (HD). The present study describes the relationship between a range of hCNTF doses and the resulting behavioral and neurochemical (striatal ChAT and GAD activity) protection in a rodent model of HD. Encapsulated BHK delivering a range of hCNTF doses were implanted into the lateral ventricle ipsilateral to an intrastriatal quinolinic acid (QA) injection. Results demonstrated a dose-dependent effect of hCNTF with complete, partial, and no observable neuroprotection occurring with preimplant doses of hCNTF of 30.8, 8.6, and 0.8–2.1 ng hCNTF/24 h, respectively. These data continue to support the use of cellular delivery of hCNTF for HD and will facilitate the optimization of this approach in the clinical situation.
url https://doi.org/10.3727/000000004783983404
work_keys_str_mv AT dwainefemerichphd dosedependentneurochemicalandfunctionalprotectionaffordedbyencapsulatedcntfproducingcells
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