Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats

Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats

We investigated the effects of chronic administration of zonisamide, an antiepileptic agent, on bone metabolism in growing rats. Administration of zonisamide at a dose of 80 mg/kg per day, s.c. for 5 weeks significantly decreased bone mineral density (BMD) at the tibial metaphysis and the diaphysis....

Full description

Bibliographic Details
Main Authors: Atsushi Takahashi, Kenji Onodera, Junzo Kamei, Shinobu Sakurada, Hisashi Shinoda, Shuichi Miyazaki, Takashi Saito, Hideaki Mayanagi
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319327148

Internet

http://www.sciencedirect.com/science/article/pii/S1347861319327148

Similar Items