Distant homology modeling of LCAT and its validation through in silico targeting and in vitro and in vivo assays.

Distant homology modeling of LCAT and its validation through in silico targeting and in vitro and in vivo assays.

LCAT (lecithin:cholesterol acyltransferase) catalyzes the transacylation of a fatty acid of lecithin to cholesterol, generating a cholesteryl ester and lysolecithin. The knowledge of LCAT atomic structure and the identification of the amino acids relevant in controlling its structure and function ar...

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Bibliographic Details
Main Authors: Cristina Sensi, Sara Simonelli, Ilaria Zanotti, Gabriella Tedeschi, Giulia Lusardi, Guido Franceschini, Laura Calabresi, Ivano Eberini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988154?pdf=render

Internet

http://europepmc.org/articles/PMC3988154?pdf=render

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