NMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders

The dorsolateral prefrontal cortex (dlPFC) generates the mental representations that are the foundation of abstract thought, and provides top-down regulation of emotion through projections to the medial PFC and cingulate cortices. Physiological recordings from dlPFC Delay cells have shown that the g...

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Bibliographic Details
Main Authors: Shengtao Yang, Hyojung Seo, Min Wang, Amy F. T. Arnsten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.654322/full