Changes in the Blood-Brain Barrier Function Are Associated With Hippocampal Neuron Death in a Kainic Acid Mouse Model of Epilepsy

Changes in the Blood-Brain Barrier Function Are Associated With Hippocampal Neuron Death in a Kainic Acid Mouse Model of Epilepsy

The kainic acid (KA)-induced epilepsy experimental model is widely used to study the mechanisms underlying this disorder. Recently, the blood-brain barrier (BBB) has become an innovative alternative treatment target for epilepsy patients. KA causes neuronal injury and BBB damage in this experimental...

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Bibliographic Details
Main Authors: Bing Chun Yan, Pei Xu, Manman Gao, Jie Wang, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Pei Qing Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neurology
Subjects:
autophagy related neuronal death
kainic acid
hippocampus CA3
tight junction proteins
PECAM-1
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00775/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00775/full

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