Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion

Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion

Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness. Universal leukoreduction significantly reduced the frequency of alloimmunization after platelet transfusion...

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Bibliographic Details
Main Authors: Anno Saris, Ivan Peyron, Pieter F. van der Meer, Tor B. Stuge, Jaap Jan Zwaginga, S. Marieke van Ham, Anja ten Brinke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
platelet
transfusion medicine
alloimmunization
storage
internalization
antigen presentation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01251/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01251/full

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