Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice

Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice

The epithelial sodium channel (ENaC) plays critical roles in maintaining fluid and electrolyte homeostasis and is located in the aldosterone-sensitive distal nephron (ASDN). We previously found that Nedd4-2 C2 knockout (KO) mice showed salt-sensitive hypertension with paradoxically enhanced ENaC gen...

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Bibliographic Details
Main Authors: Tabito Kino, Tomoaki Ishigami, Tsumugi Murata, Hiroshi Doi, Rie Nakashima-Sasaki, Lin Chen, Michiko Sugiyama, Kengo Azushima, Hiromichi Wakui, Shintaro Minegishi, Kouichi Tamura
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
salt sensitivity
hypertension
Nedd4-2 C2
eplerenone
amiloride
resistant hypertension
Online Access:http://www.mdpi.com/1422-0067/18/6/1250

Internet

http://www.mdpi.com/1422-0067/18/6/1250

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