Inferring cancer dependencies on metabolic genes from large-scale genetic screens

Inferring cancer dependencies on metabolic genes from large-scale genetic screens

Abstract Background Cancer cells reprogram their metabolism to survive and propagate. Thus, targeting metabolic rewiring in tumors is a promising therapeutic strategy. Genome-wide RNAi and CRISPR screens are powerful tools for identifying genes essential for cancer cell proliferation and survival. I...

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Bibliographic Details
Main Authors: Shoval Lagziel, Won Dong Lee, Tomer Shlomi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Biology
Subjects:
Cancer metabolism
Gene-silencing screens
RNAi
CRISPR
Tumor microenvironment
Tissue culture medium
Online Access:http://link.springer.com/article/10.1186/s12915-019-0654-4

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http://link.springer.com/article/10.1186/s12915-019-0654-4

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